Conserved Conformational Hierarchy across Functionally Divergent Glycosyltransferases of the GT-B Structural Superfamily as Determined from Microsecond Molecular Dynamics

It has long been understood that some proteins undergo conformational transitions en route to the Michaelis Complex to allow chemistry. Examination of crystal structures of glycosyltransferase enzymes in the GT-B structural class reveals that the presence of ligand in the active site triggers an ope...

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Detalles Bibliográficos
Autores principales: Ramirez-Mondragon, Carlos A., Nguyen, Megin E., Milicaj, Jozafina, Hassan, Bakar A., Tucci, Frank J., Muthyala, Ramaiah, Gao, Jiali, Taylor, Erika A., Sham, Yuk Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124905/
https://www.ncbi.nlm.nih.gov/pubmed/33924837
http://dx.doi.org/10.3390/ijms22094619

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124905/
https://www.ncbi.nlm.nih.gov/pubmed/33924837
http://dx.doi.org/10.3390/ijms22094619

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