Nuclear FGFR2 Interacts with the MLL-AF4 Oncogenic Chimera and Positively Regulates HOXA9 Gene Expression in t(4;11) Leukemia Cells

The chromosomal translocation t(4;11) marks an infant acute lymphoblastic leukemia associated with dismal prognosis. This rearrangement leads to the synthesis of the MLL-AF4 chimera, which exerts its oncogenic activity by upregulating transcription of genes involved in hematopoietic differentiation....

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Detalles Bibliográficos
Autores principales: Fioretti, Tiziana, Cevenini, Armando, Zanobio, Mariateresa, Raia, Maddalena, Sarnataro, Daniela, Cattaneo, Fabio, Ammendola, Rosario, Esposito, Gabriella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124917/
https://www.ncbi.nlm.nih.gov/pubmed/33924850
http://dx.doi.org/10.3390/ijms22094623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124917/
https://www.ncbi.nlm.nih.gov/pubmed/33924850
http://dx.doi.org/10.3390/ijms22094623

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