Effective Drug Concentration and Selectivity Depends on Fraction of Primitive Cells

Poor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has been driving the search for more active and specific compounds. In this work, we show how cell density-dependent stage culture profiles can be used in drug development workflows to achieve more robust drug activi...

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Detalles Bibliográficos
Autores principales: Lica, Jan Jakub, Wieczór, Miłosz, Grabe, Grzegorz Jan, Heldt, Mateusz, Jancz, Marta, Misiak, Majus, Gucwa, Katarzyna, Brankiewicz, Wioletta, Maciejewska, Natalia, Stupak, Anna, Bagiński, Maciej, Rolka, Krzysztof, Hellmann, Andrzej, Składanowski, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125035/
https://www.ncbi.nlm.nih.gov/pubmed/34066491
http://dx.doi.org/10.3390/ijms22094931

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125035/
https://www.ncbi.nlm.nih.gov/pubmed/34066491
http://dx.doi.org/10.3390/ijms22094931

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