Cargando…

Effective Drug Concentration and Selectivity Depends on Fraction of Primitive Cells

Poor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has been driving the search for more active and specific compounds. In this work, we show how cell density-dependent stage culture profiles can be used in drug development workflows to achieve more robust drug activi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lica, Jan Jakub, Wieczór, Miłosz, Grabe, Grzegorz Jan, Heldt, Mateusz, Jancz, Marta, Misiak, Majus, Gucwa, Katarzyna, Brankiewicz, Wioletta, Maciejewska, Natalia, Stupak, Anna, Bagiński, Maciej, Rolka, Krzysztof, Hellmann, Andrzej, Składanowski, Andrzej
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125035/ https://www.ncbi.nlm.nih.gov/pubmed/34066491 http://dx.doi.org/10.3390/ijms22094931

Ejemplares similares

Molecular basis for the DNA damage induction and anticancer activity of asymmetrically substituted anthrapyridazone PDZ-7
por: Misiak, Majus, et al.
Publicado: (2017)

Cancer immune escape: the role of antigen presentation machinery
por: Kallingal, Anoop, et al.
Publicado: (2023)

Molecular mechanism of proton-coupled ligand translocation by the bacterial efflux pump EmrE
por: Jurasz, Jakub, et al.
Publicado: (2021)

New Peptide Based Fluconazole Conjugates with Expanded Molecular Targets
por: Brankiewicz, Wioletta, et al.
Publicado: (2022)

Conjugates of Ciprofloxacin and Levofloxacin with Cell-Penetrating Peptide Exhibit Antifungal Activity and Mammalian Cytotoxicity
por: Ptaszyńska, Natalia, et al.
Publicado: (2020)

Induction of unique structural changes in guanine-rich DNA regions by the triazoloacridone C-1305, a topoisomerase II inhibitor with antitumor activities
por: Lemke, Krzysztof, et al.
Publicado: (2005)

Novel chalcone-derived pyrazoles as potential therapeutic agents for the treatment of non-small cell lung cancer
por: Maciejewska, Natalia, et al.
Publicado: (2022)

Teloxantron inhibits the processivity of telomerase with preferential DNA damage on telomeres
por: Maciejewska, Natalia, et al.
Publicado: (2022)

Relationship between Telomere Length, TERT Genetic Variability and TERT, TP53, SP1, MYC Gene Co-Expression in the Clinicopathological Profile of Breast Cancer
por: Dratwa, Marta, et al.
Publicado: (2022)

How proteins bind to DNA: target discrimination and dynamic sequence search by the telomeric protein TRF1
por: Wieczór, Miłosz, et al.
Publicado: (2017)

Photosensitive and pH-dependent activity of pyrazine-functionalized carbazole derivative as promising antifungal and imaging agent
por: Chylewska, Agnieszka, et al.
Publicado: (2020)

H2AX Phosphorylation: Its Role in DNA Damage Response and Cancer Therapy
por: Podhorecka, Monika, et al.
Publicado: (2010)

How acidic amino acid residues facilitate DNA target site selection
por: Hossain, Kazi Amirul, et al.
Publicado: (2023)

Gas Sensor Array and Classifiers as a Means of Varroosis Detection
por: Szczurek, Andrzej, et al.
Publicado: (2019)

Effect of Mineral–Microbial Deodorizing Preparation on the Value of Poultry Manure as Soil Amendment
por: Żołnowski, Andrzej Cezary, et al.
Publicado: (2022)

Omicron mutations increase interdomain interactions and reduce epitope exposure in the SARS-CoV-2 spike
por: Wieczór, Miłosz, et al.
Publicado: (2023)

Specific Activation of A(3), A(2A) and A(1) Adenosine Receptors in CD73-Knockout Mice Affects B16F10 Melanoma Growth, Neovascularization, Angiogenesis and Macrophage Infiltration
por: Koszałka, Patrycja, et al.
Publicado: (2016)

Regular subgroups of primitive permutation groups
por: Liebeck, Martin W, et al.
Publicado: (2010)

Data Networks with Satellites: Working Conference of the Joint GI/NTG
por: Majus, Joachim, et al.
Publicado: (1983)

The Effectiveness of Varroa destructor Infestation Classification Using an E-Nose Depending on the Time of Day
por: Szczurek, Andrzej, et al.
Publicado: (2020)

Molecular Recognition in Complexes of TRF Proteins with Telomeric DNA
por: Wieczór, Miłosz, et al.
Publicado: (2014)

Thermodynamics and kinetics of amphotericin B self-association in aqueous solution characterized in molecular detail
por: Zielińska, Joanna, et al.
Publicado: (2016)

Molywood: streamlining the design and rendering of molecular movies
por: Wieczór, Miłosz, et al.
Publicado: (2020)

DNAffinity: a machine-learning approach to predict DNA binding affinities of transcription factors
por: Barissi, Sandro, et al.
Publicado: (2022)

CCL2 Gene Expression and Protein Level Changes Observed in Response to Wingate Anaerobic Test in High-Trained Athletes and Non-Trained Controls
por: Maciejewska-Skrendo, Agnieszka, et al.
Publicado: (2022)

N-(4-Methylpiperazin-4-ium-1-yl)dithiocarbamate sesquihydrate
por: Mietlarek-Kropidłowska, Anna, et al.
Publicado: (2012)

Mechanism of reaction of RNA-dependent RNA polymerase from SARS-CoV-2
por: Aranda, Juan, et al.
Publicado: (2022)

Endogenous Digitalis-like Factors as a Key Molecule in the Pathophysiology of Pregnancy-Induced Hypertension and a Potential Therapeutic Target in Preeclampsia
por: Socha, Maciej W., et al.
Publicado: (2023)

Thermal Characterization of a Gas Foil Bearing—A Novel Method of Experimental Identification of the Temperature Field Based on Integrated Thermocouples Measurements
por: Martowicz, Adam, et al.
Publicado: (2022)

Primitive neuroectodermal tumor of the uterus: Excellent clinical response following a multimodal treatment approach
por: Khorasanchi, Adam, et al.
Publicado: (2020)

Primitive art
por: Boas, Franz, 1858-1942

Primitive Medicine
por: Kernohan, R. J.
Publicado: (1961)

Primitive government
por: Mair, Lucy Philip, 1901-
Publicado: (1962)

Primitive society /
por: Lowie, Robert Harry, 1883-1957
Publicado: (1961)

Primitive Tuberculosis
Publicado: (1941)

Primitive Practitioners
Publicado: (1891)

Mineral Materials as a Neutralizing Agent Used on Soil Contaminated with Copper
por: Żołnowski, Andrzej Cezary, et al.
Publicado: (2021)

PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells()
por: Węsierska-Gądek, Józefa, et al.
Publicado: (2012)

Diagnostic value of histopathological examination results obtained during screening of patients with diagnosed atypical hyperplasia
por: Malinowski, Jakub, et al.
Publicado: (2018)

Molecular mechanism and energetics of coupling between substrate binding and product release in the F(1)-ATPase catalytic cycle
por: Badocha, Michał, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_nm05s98iqo0dd3k3j8rfh7kkvd