Quantitative Proteomics Reveals that Hsp90 Inhibition Dynamically Regulates Global Protein Synthesis in Leishmania mexicana

Heat shock protein 90 (Hsp90) is a conserved molecular chaperone responsible for the folding and maturation of nascent proteins. Hsp90 is regarded as a master regulator of protein homeostasis in the cell, and its inhibition affects the functions of a large array of client proteins. The classical Hsp...

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Detalles Bibliográficos
Autores principales: Kalesh, Karunakaran, Sundriyal, Sandeep, Perera, Hirunika, Cobb, Steven L., Denny, Paul W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125071/
https://www.ncbi.nlm.nih.gov/pubmed/33975965
http://dx.doi.org/10.1128/mSystems.00089-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125071/
https://www.ncbi.nlm.nih.gov/pubmed/33975965
http://dx.doi.org/10.1128/mSystems.00089-21

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