Transcriptional Suppression of Diabetic Nephropathy with Novel Gene Silencer Pyrrole-Imidazole Polyamides Preventing USF1 Binding to the TGF-β1 Promoter

Upstream stimulatory factor 1 (USF1) is a transcription factor that is increased in high-glucose conditions and activates the transforming growth factor (TGF)-β1 promoter. We examined the effects of synthetic pyrrole-imidazole (PI) polyamides in preventing USF1 binding on the TGF-β1 promoter in Wist...

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Detalles Bibliográficos
Autores principales: Okamura, Makiyo, Fukuda, Noboru, Horikoshi, Shu, Kobayashi, Hiroki, Tsunemi, Akiko, Akiya, Yurie, Endo, Morito, Matsumoto, Taro, Abe, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125144/
https://www.ncbi.nlm.nih.gov/pubmed/33947045
http://dx.doi.org/10.3390/ijms22094741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125144/
https://www.ncbi.nlm.nih.gov/pubmed/33947045
http://dx.doi.org/10.3390/ijms22094741

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