The Neuroprotective Effects of GPR4 Inhibition through the Attenuation of Caspase Mediated Apoptotic Cell Death in an MPTP Induced Mouse Model of Parkinson’s Disease

The proton-activated G protein-coupled receptor (GPCR) 4 (GPR4) is constitutively active at physiological pH, and GPR4 knockout protected dopaminergic neurons from caspase-dependent mitochondria-associated apoptosis. This study explored the role of GPR4 in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrid...

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Detalles Bibliográficos
Autores principales: Haque, Md Ezazul, Azam, Shofiul, Akther, Mahbuba, Cho, Duk-Yeon, Kim, In-Su, Choi, Dong-Kug
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125349/
https://www.ncbi.nlm.nih.gov/pubmed/33925146
http://dx.doi.org/10.3390/ijms22094674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125349/
https://www.ncbi.nlm.nih.gov/pubmed/33925146
http://dx.doi.org/10.3390/ijms22094674

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