Cargando…

The Kynurenic Acid Analog SZR72 Enhances Neuronal Activity after Asphyxia but Is Not Neuroprotective in a Translational Model of Neonatal Hypoxic Ischemic Encephalopathy

Hypoxic–ischemic encephalopathy (HIE) remains to be a major cause of long-term neurodevelopmental deficits in term neonates. Hypothermia offers partial neuroprotection warranting research for additional therapies. Kynurenic acid (KYNA), an endogenous product of tryptophan metabolism, was previously...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kovács, Viktória, Remzső, Gábor, Körmöczi, Tímea, Berkecz, Róbert, Tóth-Szűki, Valéria, Pénzes, Andrea, Vécsei, László, Domoki, Ferenc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125407/ https://www.ncbi.nlm.nih.gov/pubmed/34062911 http://dx.doi.org/10.3390/ijms22094822

Ejemplares similares

Differential Effects of Hypothermia and SZR72 on Cerebral Kynurenine and Kynurenic Acid in a Piglet Model of Hypoxic–Ischemic Encephalopathy
por: Domoki, Ferenc, et al.
Publicado: (2023)

Inhaled H(2) or CO(2) Do Not Augment the Neuroprotective Effect of Therapeutic Hypothermia in a Severe Neonatal Hypoxic-Ischemic Encephalopathy Piglet Model
por: Kovács, Viktória, et al.
Publicado: (2020)

Brain interstitial pH changes in the subacute phase of hypoxic-ischemic encephalopathy in newborn pigs
por: Remzső, Gábor, et al.
Publicado: (2020)

Correction: Brain interstitial pH changes in the subacute phase of hypoxic-ischemic encephalopathy in newborn pigs
por: Remzső, Gábor, et al.
Publicado: (2020)

Kynurenic Acid and Its Analogue SZR-72 Ameliorate the Severity of Experimental Acute Necrotizing Pancreatitis
por: Balla, Zsolt, et al.
Publicado: (2021)

SZR-104, a Novel Kynurenic Acid Analogue with High Permeability through the Blood–Brain Barrier
por: Molnár, Kinga, et al.
Publicado: (2021)

Divergent Effects of the N-Methyl-D-Aspartate Receptor Antagonist Kynurenic Acid and the Synthetic Analog SZR-72 on Microcirculatory and Mitochondrial Dysfunction in Experimental Sepsis
por: Juhász, László, et al.
Publicado: (2020)

The kynurenic acid analog SZR104 induces cytomorphological changes associated with the anti-inflammatory phenotype in cultured microglia
por: Szabo, Melinda, et al.
Publicado: (2023)

NMDA attenuates the neurovascular response to hypercapnia in the neonatal cerebral cortex
por: Remzső, Gábor, et al.
Publicado: (2019)

Kynurenic Acid and Its Analog SZR104 Exhibit Strong Antiinflammatory Effects and Alter the Intracellular Distribution and Methylation Patterns of H3 Histones in Immunochallenged Microglia-Enriched Cultures of Newborn Rat Brains
por: Szabo, Melinda, et al.
Publicado: (2022)

Sensitivity of Rodent Microglia to Kynurenines in Models of Epilepsy and Inflammation In Vivo and In Vitro: Microglia Activation Is Inhibited by Kynurenic Acid and the Synthetic Analogue SZR104
por: Lajkó, Noémi, et al.
Publicado: (2020)

Structural Evaluation and Electrophysiological Effects of Some Kynurenic Acid Analogs
por: Fehér, Evelin, et al.
Publicado: (2019)

The Opposite Effects of Kynurenic Acid and Different Kynurenic Acid Analogs on Tumor Necrosis Factor-α (TNF-α) Production and Tumor Necrosis Factor-Stimulated Gene-6 (TSG-6) Expression
por: Mándi, Yvette, et al.
Publicado: (2019)

Kynurenic Acid and Its Analogs Are Beneficial Physiologic Attenuators in Bdelloid Rotifers
por: Datki, Zsolt, et al.
Publicado: (2019)

Topical dura mater application of CFA induces enhanced expression of c-fos and glutamate in rat trigeminal nucleus caudalis: attenuated by KYNA derivate (SZR72)
por: Lukács, M., et al.
Publicado: (2017)

KYNA analogue SZR72 modifies CFA-induced dural inflammation- regarding expression of pERK1/2 and IL-1β in the rat trigeminal ganglion
por: Lukács, M., et al.
Publicado: (2016)

Treatment device for neonatal birth asphyxia related Hypoxic Ischemic Encephalopathy
por: Zewdie, Rediet, et al.
Publicado: (2021)

Predictive modelling of hypoxic ischaemic encephalopathy risk following perinatal asphyxia
por: Mooney, Catherine, et al.
Publicado: (2021)

Regional Differences in the Neuronal Expression of Cyclooxygenase-2 (COX-2) in the Newborn Pig Brain
por: Oláh, Orsolya, et al.
Publicado: (2012)

Predictions of Hypoxic-Ischemic Encephalopathy by Umbilical Cord Blood Lactate in Newborns with Birth Asphyxia
por: Van Anh, Ton Nu, et al.
Publicado: (2019)

Glial Fibrillary Acidic Protein Is Not an Early Marker of Injury in Perinatal Asphyxia and Hypoxic–Ischemic Encephalopathy
por: Looney, Ann-Marie, et al.
Publicado: (2015)

Kidney outcomes in early adolescence following perinatal asphyxia and hypothermia-treated hypoxic-ischaemic encephalopathy
por: Robertsson Grossmann, Katarina, et al.
Publicado: (2022)

Memantine and Kynurenic Acid: Current Neuropharmacological Aspects
por: Majláth, Zsófia, et al.
Publicado: (2016)

Subcutaneous fat necrosis in neonates with hypoxic ischaemic encephalopathy registered in the Swiss National Asphyxia and Cooling Register
por: Grass, Beate, et al.
Publicado: (2015)

The Usefulness of Serum Brain Damage Biomarkers in Detection and Evaluation of Hypoxic Ischemic Encephalopathy in Calves with Perinatal Asphyxia
por: Ok, Mahmut, et al.
Publicado: (2022)

Analytical Methodologies for the Characterization and Analysis of the Parent Compound and Phase I Metabolites of 4F-MDMB-BICA in Human Microsome, Urine and Blood Samples
por: Körmöczi, Tímea, et al.
Publicado: (2021)

Memory Enhancement with Kynurenic Acid and Its Mechanisms in Neurotransmission
por: Martos, Diána, et al.
Publicado: (2022)

Natural Molecules and Neuroprotection: Kynurenic Acid, Pantethine and α-Lipoic Acid
por: Tóth, Fanni, et al.
Publicado: (2021)

Neural Function Recovery and Safety of Mild Hypothermia Therapy Combined with Monosialotetrahexosylganglioside on Neonatal Asphyxia Complicated by Hypoxic Ischemic Encephalopathy
por: Ge, Jingjing, et al.
Publicado: (2021)

Kynurenic Acid Inhibits the Electrical Stimulation Induced Elevated Pituitary Adenylate Cyclase-Activating Polypeptide Expression in the TNC
por: Körtési, Tamás, et al.
Publicado: (2018)

Kynurenic acid modulates experimentally induced inflammation in the trigeminal ganglion
por: Csáti, A., et al.
Publicado: (2015)

Retracted: Neural Function Recovery and Safety of Mild Hypothermia Therapy Combined with Monosialotetrahexosylganglioside on Neonatal Asphyxia Complicated by Hypoxic Ischemic Encephalopathy
por: Methods in Medicine, Computational and Mathematical
Publicado: (2023)

Kynurenic Acid Analog Attenuates the Production of Tumor Necrosis Factor-α, Calgranulins (S100A 8/9 and S100A 12), and the Secretion of HNP1–3 and Stimulates the Production of Tumor Necrosis Factor-Stimulated Gene-6 in Whole Blood Cultures of Patients With Rheumatoid Arthritis
por: Balog, Attila, et al.
Publicado: (2021)

Cuprizone markedly decreases kynurenic acid levels in the rodent brain tissue and plasma
por: Polyák, Helga, et al.
Publicado: (2021)

Nitroglycerin enhances the propagation of cortical spreading depression: comparative studies with sumatriptan and novel kynurenic acid analogues
por: Knapp, Levente, et al.
Publicado: (2016)

Fas-ligand and interleukin-6 in the cerebrospinal fluid are early predictors of hypoxic-ischemic encephalopathy and long-term outcomes after birth asphyxia in term infants
por: Leifsdottir, Kristin, et al.
Publicado: (2018)

Synthesis of New C-3 Substituted Kynurenic Acid Derivatives
por: Lőrinczi, Bálint, et al.
Publicado: (2020)

Perinatal Hypoxic-Ischemic Encephalopathy
por: Lai, Ming-Chi, et al.
Publicado: (2011)

Preterm Hypoxic–Ischemic Encephalopathy
por: Gopagondanahalli, Krishna Revanna, et al.
Publicado: (2016)

Unexpected effects of peripherally administered kynurenic acid on cortical spreading depression and related blood–brain barrier permeability
por: Oláh, Gáspár, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_m1o472qtboq3hlu9aghothtint