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TAS-116, a Well-Tolerated Hsp90 Inhibitor, Prevents the Activation of the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells

Chronic inflammation has been associated with several chronic diseases, such as age-related macular degeneration (AMD). The NLRP3 inflammasome is a central proinflammatory signaling complex that triggers caspase-1 activation leading to the maturation of IL-1β. We have previously shown that the inhib...

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Detalles Bibliográficos
Autores principales: Ranta-aho, Sofia, Piippo, Niina, Korhonen, Eveliina, Kaarniranta, Kai, Hytti, Maria, Kauppinen, Anu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125426/
https://www.ncbi.nlm.nih.gov/pubmed/34062977
http://dx.doi.org/10.3390/ijms22094875