Cargando…

TAS-116, a Well-Tolerated Hsp90 Inhibitor, Prevents the Activation of the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells

Chronic inflammation has been associated with several chronic diseases, such as age-related macular degeneration (AMD). The NLRP3 inflammasome is a central proinflammatory signaling complex that triggers caspase-1 activation leading to the maturation of IL-1β. We have previously shown that the inhib...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ranta-aho, Sofia, Piippo, Niina, Korhonen, Eveliina, Kaarniranta, Kai, Hytti, Maria, Kauppinen, Anu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125426/ https://www.ncbi.nlm.nih.gov/pubmed/34062977 http://dx.doi.org/10.3390/ijms22094875

Ejemplares similares

Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome
por: Piippo, Niina, et al.
Publicado: (2018)

Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation
por: Hytti, Maria, et al.
Publicado: (2015)

Effects of Resvega on Inflammasome Activation in Conjunction with Dysfunctional Intracellular Clearance in Retinal Pigment Epithelial (RPE) Cells
por: Bhattarai, Niina, et al.
Publicado: (2021)

UV-B-Induced Inflammasome Activation Can Be Prevented by Cis-Urocanic Acid in Human Corneal Epithelial Cells
por: Korhonen, Eveliina, et al.
Publicado: (2020)

The Prolyl Oligopeptidase Inhibitor KYP-2047 Is Cytoprotective and Anti-Inflammatory in Human Retinal Pigment Epithelial Cells with Defective Proteasomal Clearance
por: Toppila, Maija, et al.
Publicado: (2023)

Differential Expression of Inflammasome-Related Genes in Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells with or without History of Age-Related Macular Degeneration
por: Hytti, Maria, et al.
Publicado: (2021)

Hydroquinone Induces NLRP3-Independent IL-18 Release from ARPE-19 Cells
por: Bhattarai, Niina, et al.
Publicado: (2021)

Epoxomicin, a Selective Proteasome Inhibitor, Activates AIM2 Inflammasome in Human Retinal Pigment Epithelium Cells
por: Sridevi Gurubaran, Iswariyaraja, et al.
Publicado: (2022)

Hydroquinone predisposes for retinal pigment epithelial (RPE) cell degeneration in inflammatory conditions
por: Bhattarai, Niina, et al.
Publicado: (2022)

Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy
por: Hytti, Maria, et al.
Publicado: (2019)

Inhibition of the NLRP3 inflammasome by HSP90 inhibitors
por: Nizami, Sohaib, et al.
Publicado: (2020)

Antitumor activities of selective HSP90α/β inhibitor, TAS-116, in combination with bortezomib in multiple myeloma
por: Suzuki, Rikio, et al.
Publicado: (2014)

Resvega Alleviates Hydroquinone-Induced Oxidative Stress in ARPE-19 Cells
por: Bhattarai, Niina, et al.
Publicado: (2020)

Crosstalk of protein clearance, inflammasome, and Ca(2+) channels in retinal pigment epithelium derived from age-related macular degeneration patients
por: Karema-Jokinen, Viivi, et al.
Publicado: (2023)

Optimizing antidotal treatment with the oral HSP90 inhibitor TAS-116 against hydrochloric acid-induced pulmonary fibrosis in mice
por: Solopov, Pavel A., et al.
Publicado: (2022)

CB(2) receptor activation causes an ERK1/2-dependent inflammatory response in human RPE cells
por: Hytti, M., et al.
Publicado: (2017)

Inflammaging: disturbed interplay between autophagy and inflammasomes
por: Salminen, Antero, et al.
Publicado: (2012)

Phloretin inhibits glucose transport and reduces inflammation in human retinal pigment epithelial cells
por: Hytti, Maria, et al.
Publicado: (2022)

Isoquercitrin Attenuates Steatohepatitis by Inhibition of the Activated NLRP3 Inflammasome through HSP90
por: Ma, Ji, et al.
Publicado: (2023)

Echinatin effectively protects against NLRP3 inflammasome–driven diseases by targeting HSP90
por: Xu, Guang, et al.
Publicado: (2021)

Amyloid-β oligomers set fire to inflammasomes and induce Alzheimer's pathology
por: Salminen, Antero, et al.
Publicado: (2008)

Influence of Hsp90 and HDAC Inhibition and Tubulin Acetylation on Perinuclear Protein Aggregation in Human Retinal Pigment Epithelial Cells
por: Ryhänen, Tuomas, et al.
Publicado: (2011)

TAS‐116 (pimitespib), a heat shock protein 90 inhibitor, shows efficacy in preclinical models of adult T‐cell leukemia
por: Ikebe, Emi, et al.
Publicado: (2021)

HSP70 is a negative regulator of NLRP3 inflammasome activation
por: Martine, Pierre, et al.
Publicado: (2019)

Carnosol inhibits inflammasome activation by directly targeting HSP90 to treat inflammasome-mediated diseases
por: Shi, Wei, et al.
Publicado: (2020)

Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE-19 Cells by Triggering Erk1/2, p38(MAPK), and JNK Kinase Pathways
por: Marchesi, Nicoletta, et al.
Publicado: (2018)

Upregulation of inflammatory genes in the nasal mucosa of patients undergoing endonasal dacryocystorhinostomy
por: Penttilä, Elina, et al.
Publicado: (2014)

Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration
por: Kaarniranta, Kai, et al.
Publicado: (2013)

HSP90 acts as a senomorphic target in senescent retinal pigmental epithelial cells
por: Chen, Dan-Dan, et al.
Publicado: (2021)

NLRP3 licenses NLRP11 for inflammasome activation in human macrophages
por: Gangopadhyay, Anu, et al.
Publicado: (2022)

Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process
por: Salminen, Antero, et al.
Publicado: (2013)

Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases
por: Salminen, Antero, et al.
Publicado: (2016)

AMPK activation inhibits the functions of myeloid-derived suppressor cells (MDSC): impact on cancer and aging
por: Salminen, Antero, et al.
Publicado: (2019)

Immunosenescence: the potential role of myeloid-derived suppressor cells (MDSC) in age-related immune deficiency
por: Salminen, Antero, et al.
Publicado: (2019)

ER stress activates immunosuppressive network: implications for aging and Alzheimer’s disease
por: Salminen, Antero, et al.
Publicado: (2020)

Potential Role of Myeloid-Derived Suppressor Cells (MDSCs) in Age-Related Macular Degeneration (AMD)
por: Kauppinen, Anu, et al.
Publicado: (2020)

Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases
por: Salminen, Antero, et al.
Publicado: (2021)

Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin
por: Salminen, Antero, et al.
Publicado: (2022)

The NLRP6 inflammasome
por: Zheng, Danping, et al.
Publicado: (2020)

TAS-116 inhibits oncogenic KIT signalling on the Golgi in both imatinib-naïve and imatinib-resistant gastrointestinal stromal tumours
por: Saito, Yurina, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_s61om61c9q1v7arni60fp37spo