Cellular Mechanisms of the Anti-Arrhythmic Effect of Cardiac PDE2 Overexpression

Background: Phosphodiesterases (PDE) critically regulate myocardial cAMP and cGMP levels. PDE2 is stimulated by cGMP to hydrolyze cAMP, mediating a negative crosstalk between both pathways. PDE2 upregulation in heart failure contributes to desensitization to β-adrenergic overstimulation. After isopr...

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Detalles Bibliográficos
Autores principales: Wagner, Michael, Sadek, Mirna S., Dybkova, Nataliya, Mason, Fleur E., Klehr, Johann, Firneburg, Rebecca, Cachorro, Eleder, Richter, Kurt, Klapproth, Erik, Kuenzel, Stephan R., Lorenz, Kristina, Heijman, Jordi, Dobrev, Dobromir, El-Armouche, Ali, Sossalla, Samuel, Kämmerer, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125727/
https://www.ncbi.nlm.nih.gov/pubmed/34062838
http://dx.doi.org/10.3390/ijms22094816

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125727/
https://www.ncbi.nlm.nih.gov/pubmed/34062838
http://dx.doi.org/10.3390/ijms22094816

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