Cargando…

Cellular Mechanisms of the Anti-Arrhythmic Effect of Cardiac PDE2 Overexpression

Background: Phosphodiesterases (PDE) critically regulate myocardial cAMP and cGMP levels. PDE2 is stimulated by cGMP to hydrolyze cAMP, mediating a negative crosstalk between both pathways. PDE2 upregulation in heart failure contributes to desensitization to β-adrenergic overstimulation. After isopr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wagner, Michael, Sadek, Mirna S., Dybkova, Nataliya, Mason, Fleur E., Klehr, Johann, Firneburg, Rebecca, Cachorro, Eleder, Richter, Kurt, Klapproth, Erik, Kuenzel, Stephan R., Lorenz, Kristina, Heijman, Jordi, Dobrev, Dobromir, El-Armouche, Ali, Sossalla, Samuel, Kämmerer, Susanne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125727/ https://www.ncbi.nlm.nih.gov/pubmed/34062838 http://dx.doi.org/10.3390/ijms22094816

Ejemplares similares

Therapeutic Implications for PDE2 and cGMP/cAMP Mediated Crosstalk in Cardiovascular Diseases
por: Sadek, Mirna S., et al.
Publicado: (2020)

CNP Promotes Antiarrhythmic Effects via Phosphodiesterase 2
por: Cachorro, Eleder, et al.
Publicado: (2023)

Ion channels as part of macromolecular multiprotein complexes: Clinical significance
por: Heijman, Jordi, et al.
Publicado: (2017)

Bayesian network analyses in atrial fibrillation – A path to better therapies?()
por: Heijman, Jordi, et al.
Publicado: (2019)

Pleiotropic Effects of Antiarrhythmic Agents: Dronedarone in the Treatment of Atrial Fibrillation
por: Heijman, Jordi, et al.
Publicado: (2013)

Genome-wide association studies of atrial fibrillation: Finding meaning in the life of risk loci
por: Sutanto, Henry, et al.
Publicado: (2019)

Angiotensin Receptor-Neprilysin Inhibitor (ARNI) and Cardiac Arrhythmias
por: Sutanto, Henry, et al.
Publicado: (2021)

Emerging Antiarrhythmic Drugs for Atrial Fibrillation
por: Saljic, Arnela, et al.
Publicado: (2022)

Recent Advances in Antiarrhythmic Drug Therapy
por: Saljic, Arnela, et al.
Publicado: (2023)

Stretching the limits of antiarrhythmic drug therapy: The promise of small-conductance calcium-activated potassium channel blockers()
por: Heijman, Jordi, et al.
Publicado: (2021)

Calcium dysregulation in atrial fibrillation: the role of CaMKII
por: Heijman, Jordi, et al.
Publicado: (2014)

Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology
por: Dobrev, Dobromir, et al.
Publicado: (2022)

Counteracting Protein Kinase Activity in the Heart: The Multiple Roles of Protein Phosphatases
por: Weber, Silvio, et al.
Publicado: (2015)

Molecular and Functional Relevance of Na(V)1.8-Induced Atrial Arrhythmogenic Triggers in a Human SCN10A Knock-Out Stem Cell Model
por: Hartmann, Nico, et al.
Publicado: (2023)

Recurrence of atrial fibrillation following non-cardiac surgery or acute illness: A common but rarely detected complication
por: Barrios Espinosa, Cristian, et al.
Publicado: (2020)

Highlights from the International Journal of Cardiology Heart & Vasculature: Heart failure, atrial fibrillation, coronary artery disease and myocardial infarction
por: Linz, Dominik, et al.
Publicado: (2019)

Investigation of mesalazine as an antifibrotic drug following myocardial infarction in male mice
por: Künzel, Stephan R., et al.
Publicado: (2023)

Dual effects of the small-conductance Ca(2+)-activated K(+) current on human atrial electrophysiology and Ca(2+)-driven arrhythmogenesis: an in silico study
por: Herrera, Nathaniel T., et al.
Publicado: (2023)

Review of “Analysis and application of analog electronic circuits to biomedical instrumentation” by Robert B Northrop
por: Dobrev, Dobromir
Publicado: (2012)

Omega-3 Fatty Acids: Anti-Arrhythmic, Pro-Arrhythmic, or Both?
por: von Schacky, C.
Publicado: (2012)

Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation
por: Künzel, Stephan R., et al.
Publicado: (2021)

Treatment of the arrhythmic storm
por: Grieco, Domenico, et al.
Publicado: (2019)

Activation of PDE10 and PDE11
por: Jäger, Ronald, et al.
Publicado: (2011)

Risk stratifiers for arrhythmic and non-arrhythmic mortality after acute myocardial infarction
por: Gañán-Calvo, Alfonso M., et al.
Publicado: (2018)

Large-scale pde-constrained optimization
por: Biegler, Lorenz, et al.
Publicado: (2003)

Long-term effects of empagliflozin on excitation-contraction-coupling in human induced pluripotent stem cell cardiomyocytes
por: Pabel, Steffen, et al.
Publicado: (2020)

Mitochondrial Dysfunction Increases Arrhythmic Triggers and Substrates; Potential Anti-arrhythmic Pharmacological Targets
por: Saadeh, Khalil, et al.
Publicado: (2021)

Safety and efficacy of vernakalant for acute cardioversion of atrial fibrillation: an update
por: Tsuji, Yukiomi, et al.
Publicado: (2013)

Conventional Troponin-I versus high-sensitivity troponin-T: Performance and incremental prognostic value in non-ST-elevation acute myocardial infarction patients with negative CK-MB based on a real-world multicenter cohort
por: Ammirati, Enrico, et al.
Publicado: (2018)

Outcome of atrial fibrillation ablation in pulmonary hypertension: Is pulmonary hypertension a modifiable risk factor?
por: Linz, Dominik, et al.
Publicado: (2019)

Surgery-related cardiac stress: A susceptibility test of late atrial fibrillation recurrence?
por: Gawałko, Monika, et al.
Publicado: (2020)

Implantable cardioverter-defibrillator therapy in primary versus secondary prevention: Reliable prediction of appropriate therapies and mortality is still an unmet need
por: Tsuji, Yukiomi, et al.
Publicado: (2021)

Sleep apnea and atrial fibrillation: Update 2020
por: Linz, Dominik, et al.
Publicado: (2020)

A disproportional rise in the growing submission rate to International Journal of Cardiology Heart & Vasculature during the COVID‑19 pandemic
por: Linz, Dominik, et al.
Publicado: (2021)

Fat chance for POAF? Pericardial adipose tissue and the arrhythmogenic substrate for postoperative atrial fibrillation
por: Gawałko, Monika, et al.
Publicado: (2022)

Recent highlights on the prevalence and role of sleep disordered breathing in cardiovascular diseases from the International Journal of Cardiology Heart & Vasculature
por: Linz, Dominik, et al.
Publicado: (2023)

PDE4D and PDE4B Function in Distinct Subcellular Compartments in Mouse Embryonic Fibroblasts
por: Blackman, Brigitte E., et al.
Publicado: (2011)

Pseudo-arrhythmic ECG Artifact
por: Singh, Satyajeet, et al.
Publicado: (2012)

An antibiotic recipe for an arrhythmic disaster
por: McCutcheon, Keir, et al.
Publicado: (2015)

Genetic Deletion of Polo-Like Kinase 2 Induces a Pro-Fibrotic Pulmonary Phenotype
por: Kant, Theresa A., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_6a81d7jmpri29bieeeq89fdv78