Cargando…

Impact of uORFs in mediating regulation of translation in stress conditions

BACKGROUND: A large fraction of genes contains upstream ORFs (uORFs) in the 5′ untranslated region (5’UTR). The translation of uORFs can inhibit the translation of the main coding sequence, for example by causing premature dissociation of the two ribosomal units or ribosome stalling. However, it is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moro, Simone G., Hermans, Cedric, Ruiz-Orera, Jorge, Albà, M. Mar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126119/ https://www.ncbi.nlm.nih.gov/pubmed/33992089 http://dx.doi.org/10.1186/s12860-021-00363-9

Ejemplares similares

Impacts of uORF codon identity and position on translation regulation
por: Lin, Yizhu, et al.
Publicado: (2019)

Translational regulation by uORFs and start codon selection stringency
por: Dever, Thomas E., et al.
Publicado: (2023)

uORFlight: a vehicle toward uORF-mediated translational regulation mechanisms in eukaryotes
por: Niu, Ruixia, et al.
Publicado: (2020)

Ribo-uORF: a comprehensive data resource of upstream open reading frames (uORFs) based on ribosome profiling
por: Liu, Qi, et al.
Publicado: (2022)

uORF-mediated translation allows engineered plant disease resistance without fitness costs
por: Xu, Guoyong, et al.
Publicado: (2017)

hnRNPs and ELAVL1 cooperate with uORFs to inhibit protein translation
por: Zhang, Jiewen, et al.
Publicado: (2017)

Loss-of-function uORF mutations in human malignancies
por: Schulz, Julia, et al.
Publicado: (2018)

uORFs: Important Cis-Regulatory Elements in Plants
por: Zhang, Ting, et al.
Publicado: (2020)

uORF-Tools—Workflow for the determination of translation-regulatory upstream open reading frames
por: Scholz, Anica, et al.
Publicado: (2019)

Making Use of Plant uORFs to Control Transgene Translation in Response to Pathogen Attack
por: Ai, Gan, et al.
Publicado: (2022)

DAP5 enables main ORF translation on mRNAs with structured and uORF-containing 5′ leaders
por: Weber, Ramona, et al.
Publicado: (2022)

Determinants of genome-wide distribution and evolution of uORFs in eukaryotes
por: Zhang, Hong, et al.
Publicado: (2021)

Translation reinitiation after uORFs does not fully protect mRNAs from nonsense-mediated decay
por: Russell, Paul J., et al.
Publicado: (2023)

Fail-safe mechanism of GCN4 translational control—uORF2 promotes reinitiation by analogous mechanism to uORF1 and thus secures its key role in GCN4 expression
por: Gunišová, Stanislava, et al.
Publicado: (2014)

DENR•MCT-1 Promotes Translation Reinitiation Downstream of uORFs to Control Tissue Growth
por: Schleich, Sibylle, et al.
Publicado: (2014)

Yeast eIF2A has a minimal role in translation initiation and uORF-mediated translational control in vivo
por: Gaikwad, Swati, et al.
Publicado: (2023)

uORFdb—a comprehensive literature database on eukaryotic uORF biology
por: Wethmar, Klaus, et al.
Publicado: (2014)

The uORF-containing thrombopoietin mRNA escapes nonsense-mediated decay (NMD)
por: Stockklausner, Clemens, et al.
Publicado: (2006)

Poly(U)‐specific endoribonuclease ENDOU promotes translation of human CHOP mRNA by releasing uORF element‐mediated inhibition
por: Lee, Hung‐Chieh, et al.
Publicado: (2021)

Conservation of uORF repressiveness and sequence features in mouse, human and zebrafish
por: Chew, Guo-Liang, et al.
Publicado: (2016)

Author Correction: Loss-of-function uORF mutations in human malignancies
por: Schulz, Julia, et al.
Publicado: (2021)

Ribosomal leaky scanning through a translated uORF requires eIF4G2
por: Smirnova, Victoria V, et al.
Publicado: (2022)

Translation inhibitory elements from Hoxa3 and Hoxa11 mRNAs use uORFs for translation inhibition
por: Alghoul, Fatima, et al.
Publicado: (2021)

Application of Upstream Open Reading Frames (uORFs) Editing for the Development of Stress-Tolerant Crops
por: Um, Taeyoung, et al.
Publicado: (2021)

eIF1 modulates the recognition of suboptimal translation initiation sites and steers gene expression via uORFs
por: Fijałkowska, Daria, et al.
Publicado: (2017)

eIF1 discriminates against suboptimal initiation sites to prevent excessive uORF translation genome-wide
por: Zhou, Fujun, et al.
Publicado: (2020)

Evolutionarily conserved inhibitory uORFs sensitize Hox mRNA translation to start codon selection stringency
por: Ivanov, Ivaylo P., et al.
Publicado: (2022)

Author Correction: Determinants of genome-wide distribution and evolution of uORFs in eukaryotes
por: Zhang, Hong, et al.
Publicado: (2021)

A natural uORF variant confers phosphorus acquisition diversity in soybean
por: Guo, Zilong, et al.
Publicado: (2022)

The Emerging Role of uORF-Encoded uPeptides and HLA uLigands in Cellular and Tumor Biology
por: Jürgens, Lara, et al.
Publicado: (2022)

uORF4u: a tool for annotation of conserved upstream open reading frames
por: Egorov, Artyom A, et al.
Publicado: (2023)

TASEP modelling provides a parsimonious explanation for the ability of a single uORF to derepress translation during the integrated stress response
por: Andreev, Dmitry E, et al.
Publicado: (2018)

A Conserved uORF Regulates APOBEC3G Translation and Is Targeted by HIV-1 Vif Protein to Repress the Antiviral Factor
por: Libre, Camille, et al.
Publicado: (2021)

Charting DENR-dependent translation reinitiation uncovers predictive uORF features and links to circadian timekeeping via Clock
por: Castelo-Szekely, Violeta, et al.
Publicado: (2019)

uORF-Mediated Translational Regulation of ATF4 Serves as an Evolutionarily Conserved Mechanism Contributing to Non-Small-Cell Lung Cancer (NSCLC) and Stress Response
por: Xiao, Wenjing, et al.
Publicado: (2022)

Complexity and Conservation of Thermospermine-Responsive uORFs of SAC51 Family Genes in Angiosperms
por: Ishitsuka, Soichi, et al.
Publicado: (2019)

uORF Shuffling Fine-Tunes Gene Expression at a Deep Level of the Process
por: Kurihara, Yukio
Publicado: (2020)

Annotation of uORFs in the OMIM genes allows to reveal pathogenic variants in 5′UTRs
por: Filatova, Alexandra, et al.
Publicado: (2023)

Gcn2 eIF2α kinase mediates combinatorial translational regulation through nucleotide motifs and uORFs in target mRNAs
por: Chikashige, Yuji, et al.
Publicado: (2020)

Development of nanoRibo-seq enables study of regulated translation by cortical neuron subtypes, showing uORF translation in synaptic-axonal genes
por: Froberg, John E., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_gc49altk110pdvq9pinuhhpuol