WDR45 Mutation Impairs the Autophagic Degradation of Transferrin Receptor and Promotes Ferroptosis

WDR45 is an autophagy-related protein that involves in the formation of autophagosome. Mutations in WDR45 lead to the impairment of autophagy which is associated with the human β-propeller protein-associated neurodegeneration (BPAN). However, the relationship between autophagy and brain iron accumul...

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Detalles Bibliográficos
Autores principales: Xiong, Qiuhong, Li, Xin, Li, Wenjing, Chen, Guangxin, Xiao, Han, Li, Ping, Wu, Changxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126626/
https://www.ncbi.nlm.nih.gov/pubmed/34012978
http://dx.doi.org/10.3389/fmolb.2021.645831

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126626/
https://www.ncbi.nlm.nih.gov/pubmed/34012978
http://dx.doi.org/10.3389/fmolb.2021.645831

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