Cargando…
Plasmodium falciparum LipB mutants display altered redox and carbon metabolism in asexual stages and cannot complete sporogony in Anopheles mosquitoes
Malaria is still one of the most important global infectious diseases. Emergence of drug resistance and a shortage of new efficient antimalarials continue to hamper a malaria eradication agenda. Malaria parasites are highly sensitive to changes in the redox environment. Understanding the mechanisms...
Autores principales: | Biddau, Marco, Santha Kumar, T.R., Henrich, Philipp, Laine, Larissa M., Blackburn, Gavin J., Chokkathukalam, Achuthanunni, Li, Tao, Lee Sim, Kim, King, Lewis, Hoffman, Stephen L., Barrett, Michael P., Coombs, Graham H., McFadden, Geoffrey I., Fidock, David A., Müller, Sylke, Sheiner, Lilach |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Science
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126644/ https://www.ncbi.nlm.nih.gov/pubmed/33713652 http://dx.doi.org/10.1016/j.ijpara.2020.10.011 |
Ejemplares similares
-
Efficient display of active lipase LipB52 with a Pichia pastoris cell surface display system and comparison with the LipB52 displayed on Saccharomyces cerevisiae cell surface
por: Jiang, Zhengbing, et al.
Publicado: (2008) -
Phosphoenolpyruvate Carboxylase Identified as a Key Enzyme in Erythrocytic Plasmodium falciparum Carbon Metabolism
por: Storm, Janet, et al.
Publicado: (2014) -
Protein–protein interaction based substrate control in the E. coli octanoic acid transferase, LipB
por: Bartholow, Thomas G., et al.
Publicado: (2021) -
Ivermectin inhibits the sporogony of Plasmodium falciparum in Anopheles gambiae
por: Kobylinski, Kevin C, et al.
Publicado: (2012) -
Biochemical and structural characterization of the apicoplast dihydrolipoamide dehydrogenase of Plasmodium falciparum
por: Laine, Larissa M., et al.
Publicado: (2015)