PI(3,4)P(2)-mediated membrane tubulation promotes integrin trafficking and invasive cell migration

Invadopodia are integrin-mediated adhesions with abundant PI(3,4)P(2). However, the functional role of PI(3,4)P(2) in adhesion signaling remains unclear. Here, we find that the PI(3,4)P(2) biogenesis regulates the integrin endocytosis at invadopodia. PI(3,4)P(2) is locally produced by PIK3CA and SHI...

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Detalles Bibliográficos
Autores principales: Feng, Zhen, Yu, Cheng-han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126793/
https://www.ncbi.nlm.nih.gov/pubmed/33947811
http://dx.doi.org/10.1073/pnas.2017645118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126793/
https://www.ncbi.nlm.nih.gov/pubmed/33947811
http://dx.doi.org/10.1073/pnas.2017645118

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