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PI(3,4)P(2)-mediated membrane tubulation promotes integrin trafficking and invasive cell migration
Invadopodia are integrin-mediated adhesions with abundant PI(3,4)P(2). However, the functional role of PI(3,4)P(2) in adhesion signaling remains unclear. Here, we find that the PI(3,4)P(2) biogenesis regulates the integrin endocytosis at invadopodia. PI(3,4)P(2) is locally produced by PIK3CA and SHI...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126793/ https://www.ncbi.nlm.nih.gov/pubmed/33947811 http://dx.doi.org/10.1073/pnas.2017645118 |