BNIP3 promotes HIF‐1α‐driven melanoma growth by curbing intracellular iron homeostasis

BNIP3 is a mitophagy receptor with context‐dependent roles in cancer, but whether and how it modulates melanoma growth in vivo remains unknown. Here, we found that elevated BNIP3 levels correlated with poorer melanoma patient’s survival and depletion of BNIP3 in B16‐F10 melanoma cells compromised tu...

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Detalles Bibliográficos
Autores principales: Vara‐Pérez, Mónica, Rossi, Matteo, Van den Haute, Chris, Maes, Hannelore, Sassano, Maria Livia, Venkataramani, Vivek, Michalke, Bernhard, Romano, Erminia, Rillaerts, Kristine, Garg, Abhishek D, Schepkens, Corentin, Bosisio, Francesca M, Wouters, Jasper, Oliveira, Ana Isabel, Vangheluwe, Peter, Annaert, Wim, Swinnen, Johannes V, Colet, Jean Marie, van den Oord, Joost J, Fendt, Sarah‐Maria, Mazzone, Massimiliano, Agostinis, Patrizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126921/
https://www.ncbi.nlm.nih.gov/pubmed/33932034
http://dx.doi.org/10.15252/embj.2020106214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126921/
https://www.ncbi.nlm.nih.gov/pubmed/33932034
http://dx.doi.org/10.15252/embj.2020106214

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