Second-generation tricyclic pyrimido-pyrrolo-oxazine mTOR inhibitor with predicted blood–brain barrier permeability

Highly selective mTOR inhibitors have been discovered through the exploration of the heteroaromatic ring engaging the binding affinity region in mTOR kinase. Compound 11 showed predicted BBB permeability in a MDCK-MDR1 permeability in vitro assay, being the first pyrimido-pyrrolo-oxazine with potent...

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Detalles Bibliográficos
Autores principales: Borsari, Chiara, Keles, Erhan, Treyer, Andrea, De Pascale, Martina, Hebeisen, Paul, Hamburger, Matthias, Wymann, Matthias P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128076/
https://www.ncbi.nlm.nih.gov/pubmed/34041490
http://dx.doi.org/10.1039/d0md00408a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128076/
https://www.ncbi.nlm.nih.gov/pubmed/34041490
http://dx.doi.org/10.1039/d0md00408a

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