HDAC2 links ubiquitination to tumor suppression in synovial sarcoma

The function of histone deacetylase 2 (HDAC2) in transcriptional regulation and its role in oncogenesis have been well established. Here we discuss a transcription-independent HDAC2 pathway controlling cancer-related protein stability via the mouse double minute 2 homolog (MDM2) ubiquitin ligase. In...

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Detalles Bibliográficos
Autores principales: Cooley, Christina, Su, Le
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128193/
https://www.ncbi.nlm.nih.gov/pubmed/34027048
http://dx.doi.org/10.1080/23723556.2021.1914291
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author Cooley, Christina
Su, Le
author_facet Cooley, Christina
Su, Le
author_sort Cooley, Christina
collection PubMed
description The function of histone deacetylase 2 (HDAC2) in transcriptional regulation and its role in oncogenesis have been well established. Here we discuss a transcription-independent HDAC2 pathway controlling cancer-related protein stability via the mouse double minute 2 homolog (MDM2) ubiquitin ligase. In synovial sarcoma, HDAC2 inactivation demonstrates significant therapeutic effect by degradation of the SS18-SSX driver oncoprotein.
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spelling pubmed-81281932021-05-21 HDAC2 links ubiquitination to tumor suppression in synovial sarcoma Cooley, Christina Su, Le Mol Cell Oncol Commentary The function of histone deacetylase 2 (HDAC2) in transcriptional regulation and its role in oncogenesis have been well established. Here we discuss a transcription-independent HDAC2 pathway controlling cancer-related protein stability via the mouse double minute 2 homolog (MDM2) ubiquitin ligase. In synovial sarcoma, HDAC2 inactivation demonstrates significant therapeutic effect by degradation of the SS18-SSX driver oncoprotein. Taylor & Francis 2021-04-25 /pmc/articles/PMC8128193/ /pubmed/34027048 http://dx.doi.org/10.1080/23723556.2021.1914291 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Commentary
Cooley, Christina
Su, Le
HDAC2 links ubiquitination to tumor suppression in synovial sarcoma
title HDAC2 links ubiquitination to tumor suppression in synovial sarcoma
title_full HDAC2 links ubiquitination to tumor suppression in synovial sarcoma
title_fullStr HDAC2 links ubiquitination to tumor suppression in synovial sarcoma
title_full_unstemmed HDAC2 links ubiquitination to tumor suppression in synovial sarcoma
title_short HDAC2 links ubiquitination to tumor suppression in synovial sarcoma
title_sort hdac2 links ubiquitination to tumor suppression in synovial sarcoma
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128193/
https://www.ncbi.nlm.nih.gov/pubmed/34027048
http://dx.doi.org/10.1080/23723556.2021.1914291
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