Limited inhibition of multiple nodes in a driver network blocks metastasis

Metastasis suppression by high-dose, multi-drug targeting is unsuccessful due to network heterogeneity and compensatory network activation. Here, we show that targeting driver network signaling capacity by limited inhibition of core pathways is a more effective anti-metastatic strategy. This princip...

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Detalles Bibliográficos
Autores principales: Yesilkanal, Ali Ekrem, Yang, Dongbo, Valdespino, Andrea, Tiwari, Payal, Sabino, Alan U, Nguyen, Long Chi, Lee, Jiyoung, Xie, Xiao-He, Sun, Siqi, Dann, Christopher, Robinson-Mailman, Lydia, Steinberg, Ethan, Stuhlmiller, Timothy, Frankenberger, Casey, Goldsmith, Elizabeth, Johnson, Gary L, Ramos, Alexandre F, Rosner, Marsha R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128439/
https://www.ncbi.nlm.nih.gov/pubmed/33973518
http://dx.doi.org/10.7554/eLife.59696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128439/
https://www.ncbi.nlm.nih.gov/pubmed/33973518
http://dx.doi.org/10.7554/eLife.59696

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