OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21

Adrenergic stimulation of brown adipocytes alters mitochondrial dynamics, including the mitochondrial fusion protein optic atrophy 1 (OPA1). However, direct mechanisms linking OPA1 to brown adipose tissue (BAT) physiology are incompletely understood. We utilized a mouse model of selective OPA1 delet...

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Detalles Bibliográficos
Autores principales: Pereira, Renata O, Marti, Alex, Olvera, Angela Crystal, Tadinada, Satya Murthy, Bjorkman, Sarah Hartwick, Weatherford, Eric Thomas, Morgan, Donald A, Westphal, Michael, Patel, Pooja H, Kirby, Ana Karina, Hewezi, Rana, Bùi Trân, William, García-Peña, Luis Miguel, Souvenir, Rhonda A, Mittal, Monika, Adams, Christopher M, Rahmouni, Kamal, Potthoff, Matthew J, Abel, E Dale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128440/
https://www.ncbi.nlm.nih.gov/pubmed/33944779
http://dx.doi.org/10.7554/eLife.66519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128440/
https://www.ncbi.nlm.nih.gov/pubmed/33944779
http://dx.doi.org/10.7554/eLife.66519

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