Towards Evidence-Based Weaning: a Mechanism-Based Pharmacometric Model to Characterize Iatrogenic Withdrawal Syndrome in Critically Ill Children

For the management of iatrogenic withdrawal syndrome (IWS) in children, a quantitative understanding of the dynamics of IWS of commonly used opioids and sedatives is lacking. Here, we introduce a new mechanism-based pharmacokinetic-pharmacodynamic (PKPD) modeling approach for studying IWS in pediatr...

Descripción completa

Detalles Bibliográficos
Autores principales: Goulooze, Sebastiaan C., Ista, Erwin, van Dijk, Monique, Tibboel, Dick, Krekels, Elke H. J., Knibbe, Catherijne A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128736/
https://www.ncbi.nlm.nih.gov/pubmed/34002290
http://dx.doi.org/10.1208/s12248-021-00586-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128736/
https://www.ncbi.nlm.nih.gov/pubmed/34002290
http://dx.doi.org/10.1208/s12248-021-00586-w

Ejemplares similares