Development and characterization of a monoclonal antibody blocking human TRPM4 channel

TRPM4 is a calcium-activated non-selective monovalent cation channel implicated in diseases such as stroke. Lack of potent and selective inhibitors remains a major challenge for studying TRPM4. Using a polypeptide from rat TRPM4, we have generated a polyclonal antibody M4P which could alleviate repe...

Descripción completa

Detalles Bibliográficos
Autores principales: Low, See Wee, Gao, Yahui, Wei, Shunhui, Chen, Bo, Nilius, Bernd, Liao, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129085/
https://www.ncbi.nlm.nih.gov/pubmed/34002002
http://dx.doi.org/10.1038/s41598-021-89935-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129085/
https://www.ncbi.nlm.nih.gov/pubmed/34002002
http://dx.doi.org/10.1038/s41598-021-89935-5

Ejemplares similares