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Development and characterization of a monoclonal antibody blocking human TRPM4 channel

TRPM4 is a calcium-activated non-selective monovalent cation channel implicated in diseases such as stroke. Lack of potent and selective inhibitors remains a major challenge for studying TRPM4. Using a polypeptide from rat TRPM4, we have generated a polyclonal antibody M4P which could alleviate repe...

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Detalles Bibliográficos
Autores principales:	Low, See Wee, Gao, Yahui, Wei, Shunhui, Chen, Bo, Nilius, Bernd, Liao, Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129085/ https://www.ncbi.nlm.nih.gov/pubmed/34002002 http://dx.doi.org/10.1038/s41598-021-89935-5

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