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Proline codon pair selection determines ribosome pausing strength and translation efficiency in bacteria
The speed of mRNA translation depends in part on the amino acid to be incorporated into the nascent chain. Peptide bond formation is especially slow with proline and two adjacent prolines can even cause ribosome stalling. While previous studies focused on how the amino acid context of a Pro-Pro moti...
Autores principales: | Krafczyk, Ralph, Qi, Fei, Sieber, Alina, Mehler, Judith, Jung, Kirsten, Frishman, Dmitrij, Lassak, Jürgen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129111/ https://www.ncbi.nlm.nih.gov/pubmed/34002016 http://dx.doi.org/10.1038/s42003-021-02115-z |
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