SIRT3 overexpression and epigenetic silencing of catalase regulate ROS accumulation in CLL cells activating AXL signaling axis

Mitochondrial metabolism is the key source for abundant ROS in chronic lymphocytic leukemia (CLL) cells. Here, we detected significantly lower superoxide anion (O(2)(−)) levels with increased accumulation of hydrogen peroxide (H(2)O(2)) in CLL cells vs. normal B-cells. Further analysis indicated tha...

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Detalles Bibliográficos
Autores principales: Maiti, Guru P., Sinha, Sutapa, Mahmud, Hasan, Boysen, Justin, Mendez, Mariana T., Vesely, Sara K., Holter-Chakrabarty, Jennifer, Kay, Neil E., Ghosh, Asish K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129117/
https://www.ncbi.nlm.nih.gov/pubmed/34001853
http://dx.doi.org/10.1038/s41408-021-00484-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129117/
https://www.ncbi.nlm.nih.gov/pubmed/34001853
http://dx.doi.org/10.1038/s41408-021-00484-6

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