Bridging across patient subgroups in phase I oncology trials that incorporate animal data

In this paper, we develop a general Bayesian hierarchical model for bridging across patient subgroups in phase I oncology trials, for which preliminary information about the dose–toxicity relationship can be drawn from animal studies. Parameters that re-scale the doses to adjust for intrinsic differ...

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Detalles Bibliográficos
Autores principales: Zheng, Haiyan, Hampson, Lisa V, Jaki, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129464/
https://www.ncbi.nlm.nih.gov/pubmed/33501882
http://dx.doi.org/10.1177/0962280220986580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129464/
https://www.ncbi.nlm.nih.gov/pubmed/33501882
http://dx.doi.org/10.1177/0962280220986580

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