Alzheimer mutant speeds APP transport

APP(S198P) segregates with rare familial forms of Alzheimer’s disease and resides within exon 5, unlike 27 other mutations that reside in exons 16 or 17. In this issue, Zhang et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20210313) show that the brains of APP(S198P) transgenic mice accumulat...

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Detalles Bibliográficos
Autores principales: Gandy, Sam, Ehrlich, Michelle E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129791/
https://www.ncbi.nlm.nih.gov/pubmed/33988687
http://dx.doi.org/10.1084/jem.20210511
Descripción
Sumario:APP(S198P) segregates with rare familial forms of Alzheimer’s disease and resides within exon 5, unlike 27 other mutations that reside in exons 16 or 17. In this issue, Zhang et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20210313) show that the brains of APP(S198P) transgenic mice accumulate excess levels of Aβ. In cultured cells, APP(S198P) undergoes accelerated ER folding, leading to early arrival in late vesicular compartments, thereby enhancing generation of Aβ.

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