Chromosome oscillation promotes Aurora A–dependent Hec1 phosphorylation and mitotic fidelity

Most cancer cells show chromosomal instability, a condition where chromosome missegregation occurs frequently. We found that chromosome oscillation, an iterative chromosome motion during metaphase, is attenuated in cancer cell lines. We also found that metaphase phosphorylation of Hec1 at serine 55,...

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Detalles Bibliográficos
Autores principales: Iemura, Kenji, Natsume, Toyoaki, Maehara, Kayoko, Kanemaki, Masato T., Tanaka, Kozo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129796/
https://www.ncbi.nlm.nih.gov/pubmed/33988677
http://dx.doi.org/10.1083/jcb.202006116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129796/
https://www.ncbi.nlm.nih.gov/pubmed/33988677
http://dx.doi.org/10.1083/jcb.202006116

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