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A participant-derived xenograft model of HIV enables long-term evaluation of autologous immunotherapies
HIV-specific CD8(+) T cells partially control viral replication and delay disease progression, but they rarely provide lasting protection, largely due to immune escape. Here, we show that engrafting mice with memory CD4(+) T cells from HIV(+) donors uniquely allows for the in vivo evaluation of auto...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129803/ https://www.ncbi.nlm.nih.gov/pubmed/33988715 http://dx.doi.org/10.1084/jem.20201908 |