A participant-derived xenograft model of HIV enables long-term evaluation of autologous immunotherapies

HIV-specific CD8(+) T cells partially control viral replication and delay disease progression, but they rarely provide lasting protection, largely due to immune escape. Here, we show that engrafting mice with memory CD4(+) T cells from HIV(+) donors uniquely allows for the in vivo evaluation of auto...

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Detalles Bibliográficos
Autores principales: McCann, Chase D., van Dorp, Christiaan H., Danesh, Ali, Ward, Adam R., Dilling, Thomas R., Mota, Talia M., Zale, Elizabeth, Stevenson, Eva M., Patel, Shabnum, Brumme, Chanson J., Dong, Winnie, Jones, Douglas S., Andresen, Thomas L., Walker, Bruce D., Brumme, Zabrina L., Bollard, Catherine M., Perelson, Alan S., Irvine, Darrell J., Jones, R. Brad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Technical Advances and Resources
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129803/
https://www.ncbi.nlm.nih.gov/pubmed/33988715
http://dx.doi.org/10.1084/jem.20201908

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