Cargando…

Surface-modified engineered exosomes attenuated cerebral ischemia/reperfusion injury by targeting the delivery of quercetin towards impaired neurons

BACKGROUND: The incidence of ischemic stroke in the context of vascular disease is high, and the expression of growth-associated protein-43 (GAP43) increases when neurons are damaged or stimulated, especially in a rat model of middle cerebral artery occlusion/reperfusion (MCAO/R). EXPERIMENTAL: DESI...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, Lin, Huang, Zhixuan, Huang, Lijuan, Liang, Jia, Wang, Peng, Zhao, Liang, Shi, Yijie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130330/ https://www.ncbi.nlm.nih.gov/pubmed/34001136 http://dx.doi.org/10.1186/s12951-021-00879-4

Ejemplares similares

Brain-targeted heptapeptide-loaded exosomes attenuated ischemia–reperfusion injury by promoting the transfer of healthy mitochondria from astrocytes to neurons
por: Liu, Wei, et al.
Publicado: (2022)

Ischemic Postconditioning Protects Neuronal Death Caused by Cerebral Ischemia and Reperfusion via Attenuating Protein Aggregation
por: Liang, Jianmin, et al.
Publicado: (2012)

Exosomes in Cerebral Ischemia-Reperfusion Injury: Current Perspectives and Future Challenges
por: Zhou, Chao, et al.
Publicado: (2022)

MiR-375 attenuates injury of cerebral ischemia/reperfusion via targetting Ctgf
por: Ou, Jianying, et al.
Publicado: (2017)

Quercetin Liposomal Nanoformulation for Ischemia and Reperfusion Injury Treatment
por: Ferreira-Silva, Margarida, et al.
Publicado: (2022)

Quercetin for myocardial ischemia reperfusion injury: A protocol for systematic review and meta-analysis
por: Lu, Liying, et al.
Publicado: (2020)

Brain delivery of quercetin-loaded exosomes improved cognitive function in AD mice by inhibiting phosphorylated tau-mediated neurofibrillary tangles
por: Qi, Yao, et al.
Publicado: (2020)

Dexmedetomidine attenuates neuronal injury induced by cerebral ischemia-reperfusion by regulating miR-199a
por: Zhu, Yulin, et al.
Publicado: (2021)

Flurbiprofen axetil attenuates cerebral ischemia/reperfusion injury by reducing inflammation in a rat model of transient global cerebral ischemia/reperfusion
por: Wu, Huisheng, et al.
Publicado: (2018)

Neuronal Regeneration after Electroacupuncture Treatment in Ischemia–Reperfusion-Injured Cerebral Infarction Rats
por: Liao, Shiang-Lin, et al.
Publicado: (2017)

Berberine Attenuates Cerebral Ischemia-Reperfusion Injury Induced Neuronal Apoptosis by Down-Regulating the CNPY2 Signaling Pathway
por: Zhao, Lina, et al.
Publicado: (2021)

Effect of minocycline on cerebral ischemia-reperfusion injury★
por: Zheng, Yuanyin, et al.
Publicado: (2013)

Preparation of gastrodin‐modified dendrimer‐entrapped gold nanoparticles as a drug delivery system for cerebral ischemia–reperfusion injury
por: Huang, Wenqiang, et al.
Publicado: (2022)

Cardioprotective Effects of Quercetin in Cardiomyocyte under Ischemia/Reperfusion Injury
por: Chen, Yi-Wen, et al.
Publicado: (2013)

Protective Mechanisms of Quercetin Against Myocardial Ischemia Reperfusion Injury
por: Zhang, Yu-Min, et al.
Publicado: (2020)

Anti-CHAC1 exosomes for nose-to-brain delivery of miR-760-3p in cerebral ischemia/reperfusion injury mice inhibiting neuron ferroptosis
por: Wang, Yong, et al.
Publicado: (2023)

Nose-to-brain delivery of borneol modified tanshinone IIA nanoparticles in prevention of cerebral ischemia/reperfusion injury
por: Wang, Luting, et al.
Publicado: (2021)

Sodium hydrosulfide attenuates cerebral ischemia/reperfusion injury by suppressing overactivated autophagy in rats
por: Jiang, Wen‐Wu, et al.
Publicado: (2017)

Neuroprotective Role of Nanoencapsulated Quercetin in Combating Ischemia-Reperfusion Induced Neuronal Damage in Young and Aged Rats
por: Ghosh, Aparajita, et al.
Publicado: (2013)

Circ-camk4 involved in cerebral ischemia/reperfusion induced neuronal injury
por: Zhang, Zhao-huan, et al.
Publicado: (2020)

CHIP ameliorates cerebral ischemia-reperfusion injury by attenuating necroptosis and inflammation
por: Yao, Dabao, et al.
Publicado: (2021)

Treadmill training attenuates pyroptosis in rats with cerebral ischemia/reperfusion injury
por: Luo, Fang, et al.
Publicado: (2022)

Quercetin postconditioning attenuates myocardial ischemia/reperfusion injury in rats through the PI3K/Akt pathway
por: Wang, Y., et al.
Publicado: (2013)

The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment
por: Egashira, Yusuke, et al.
Publicado: (2013)

Brain Microvascular Endothelial Cell-Derived Exosomes Protect Neurons from Ischemia–Reperfusion Injury in Mice
por: Sun, Jin, et al.
Publicado: (2022)

Upregulation of CDGSH iron sulfur domain 2 attenuates cerebral ischemia/reperfusion injury
por: Hu, Miao, et al.
Publicado: (2022)

Stigmasterol alleviates cerebral ischemia/reperfusion injury by attenuating inflammation and improving antioxidant defenses in rats
por: Liang, Qilong, et al.
Publicado: (2020)

RETRACTED ARTICLE: Restored microRNA-326-5p Inhibits Neuronal Apoptosis and Attenuates Mitochondrial Damage via Suppressing STAT3 in Cerebral Ischemia/Reperfusion Injury
por: Huang, Yumin, et al.
Publicado: (2021)

Retraction Note: Restored microRNA-326-5p Inhibits Neuronal Apoptosis and Attenuates Mitochondrial Damage via Suppressing STAT3 in Cerebral Ischemia/Reperfusion Injury
por: Huang, Yumin, et al.
Publicado: (2022)

TMEM16F Aggravates Neuronal Loss by Mediating Microglial Phagocytosis of Neurons in a Rat Experimental Cerebral Ischemia and Reperfusion Model
por: Zhang, Yijie, et al.
Publicado: (2020)

Tetrandrine attenuates ischemia/reperfusion-induced neuronal damage in the subacute phase
por: Wang, Yu, et al.
Publicado: (2021)

Mitophagy in Cerebral Ischemia and Ischemia/Reperfusion Injury
por: Shen, Luoan, et al.
Publicado: (2021)

Quercetin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy by Inhibiting ERK/NF-κB Pathway
por: Wu, Liwei, et al.
Publicado: (2017)

Mechanical Reperfusion Following Prolonged Global Cerebral Ischemia Attenuates Brain Injury
por: Lindblom, Rickard P. F., et al.
Publicado: (2020)

Sodium danshensu attenuates cerebral ischemia–reperfusion injury by targeting AKT1
por: Gao, Qing, et al.
Publicado: (2022)

ESE1 expression correlates with neuronal apoptosis in the hippocampus after cerebral ischemia/reperfusion injury
por: Yu, Hai-Long, et al.
Publicado: (2019)

Protective Role of Fucoidan in Cerebral Ischemia-Reperfusion Injury through Inhibition of MAPK Signaling Pathway
por: Che, Nan, et al.
Publicado: (2017)

Engineering exosomes for targeted drug delivery
por: Liang, Yujie, et al.
Publicado: (2021)

Effects of thymosin β4 on neuronal apoptosis in a rat model of cerebral ischemia-reperfusion injury
por: Zhang, Zhongsheng, et al.
Publicado: (2019)

Adiponectin Treatment Attenuates Cerebral Ischemia-Reperfusion Injury through HIF-1α-Mediated Antioxidation in Mice
por: Zhang, Chan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_skpljm8bputmvqduvf1r6051pf