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mTOR controls endoplasmic reticulum–Golgi apparatus trafficking of VSVg in specific cell types

BACKGROUND: Mammalian/mechanistic target of rapamycin (mTOR) complexes are essential for cell proliferation, growth, differentiation, and survival. mTORC1 hyperactivation occurs in the tuberous sclerosis complex (TSC). mTORC1 localizes to the surface of lysosomes, where Rheb activates it. However, m...

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Detalles Bibliográficos
Autores principales: Koscielny, Alicja, Liszewska, Ewa, Machnicka, Katarzyna, Wezyk, Michalina, Kotulska, Katarzyna, Jaworski, Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130434/
https://www.ncbi.nlm.nih.gov/pubmed/34006213
http://dx.doi.org/10.1186/s11658-021-00262-z