Cargando…
Estimating colocalization probability from limited summary statistics
BACKGROUND: Colocalization is a statistical method used in genetics to determine whether the same variant is causal for multiple phenotypes, for example, complex traits and gene expression. It provides stronger mechanistic evidence than shared significance, which can be produced through separate cau...
Autores principales: | King, Emily A., Dunbar, Fengjiao, Davis, Justin Wade, Degner, Jacob F. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130535/ https://www.ncbi.nlm.nih.gov/pubmed/34000989 http://dx.doi.org/10.1186/s12859-021-04170-z |
Ejemplares similares
-
Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval
por: King, Emily A., et al.
Publicado: (2019) -
Gene set bagging for estimating the probability a statistically significant result will replicate
por: Jaffe, Andrew E, et al.
Publicado: (2013) -
Pitfalls in methods to study colocalization of nanoparticles in mouse macrophage lysosomes
por: Moreno-Echeverri, Aura Maria, et al.
Publicado: (2022) -
Risk estimation using probability machines
por: Dasgupta, Abhijit, et al.
Publicado: (2014) -
Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics
por: Holland, Dominic, et al.
Publicado: (2016)