Discovery, affinity maturation and multimerization of small molecule ligands against human tyrosinase and tyrosinase-related protein 1

Human tyrosinase (hTYR) and tyrosinase-related protein 1 (hTYRP1) are closely-related enzymes involved in the synthesis of melanin, which are selectively expressed in melanocytes and, in a pathological context, in melanoma lesions. We used a previously described tyrosinase inhibitor (Thiamidol™) and...

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Detalles Bibliográficos
Autores principales: Catalano, Marco, Bassi, Gabriele, Rotondi, Giulia, Khettabi, Lyna, Dichiara, Maria, Murer, Patrizia, Scheuermann, Jörg, Soler-Lopez, Montserrat, Neri, Dario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130610/
https://www.ncbi.nlm.nih.gov/pubmed/34041485
http://dx.doi.org/10.1039/d0md00310g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130610/
https://www.ncbi.nlm.nih.gov/pubmed/34041485
http://dx.doi.org/10.1039/d0md00310g

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