Fragment-based drug discovery: opportunities for organic synthesis

This Review describes the increasing demand for organic synthesis to facilitate fragment-based drug discovery (FBDD), focusing on polar, unprotected fragments. In FBDD, X-ray crystal structures are used to design target molecules for synthesis with new groups added onto a fragment via specific growt...

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Detalles Bibliográficos
Autores principales: St. Denis, Jeffrey D., Hall, Richard J., Murray, Christopher W., Heightman, Tom D., Rees, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130625/
https://www.ncbi.nlm.nih.gov/pubmed/34041484
http://dx.doi.org/10.1039/d0md00375a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130625/
https://www.ncbi.nlm.nih.gov/pubmed/34041484
http://dx.doi.org/10.1039/d0md00375a

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