Cargando…
Gaining acceptance in next generation PBK modelling approaches for regulatory assessments – An OECD international effort
Physiologically Based Kinetic (PBK) models are valuable tools to help define safe external levels of chemicals based on internal doses at target organs in experimental animals, humans and organisms used in environmental risk assessment. As the toxicity testing paradigm shifts to alternative testing...
Autores principales: | Paini, Alicia, Tan, Yu-Mei, Sachana, Magdalini, Worth, Andrew |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130668/ https://www.ncbi.nlm.nih.gov/pubmed/34027244 http://dx.doi.org/10.1016/j.comtox.2021.100163 |
Ejemplares similares
-
Toward a Better Testing Paradigm for Developmental Neurotoxicity: OECD Efforts and Regulatory Considerations
por: Sachana, Magdalini, et al.
Publicado: (2021) -
Next generation physiologically based kinetic (NG-PBK) models in support of regulatory decision making
por: Paini, A., et al.
Publicado: (2019) -
Investigating the state of physiologically based kinetic modelling practices and challenges associated with gaining regulatory acceptance of model applications
por: Paini, Alicia, et al.
Publicado: (2017) -
Physiologically based kinetic (PBK) modelling and human biomonitoring data for mixture risk assessment
por: Pletz, Julia, et al.
Publicado: (2020) -
Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment
por: Najjar, Abdulkarim, et al.
Publicado: (2022)