Structure and activation mechanism of the human liver-type glutaminase GLS2

Cancer cells exhibit an altered metabolic phenotype, consuming higher levels of the amino acid glutamine. This metabolic reprogramming depends on increased mitochondrial glutaminase activity to convert glutamine to glutamate, an essential precursor for bioenergetic and biosynthetic processes in cell...

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Detalles Bibliográficos
Autores principales: Ferreira, Igor M., Quesñay, José Edwin N., Bastos, Alliny CS., Rodrigues, Camila T., Vollmar, Melanie, Krojer, Tobias, Strain-Damerell, Claire, Burgess-Brown, Nicola A., von Delft, Frank, Yue, Wyatt W., Dias, Sandra MG., Ambrosio, Andre LB.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editions Scientifiques Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130709/
https://www.ncbi.nlm.nih.gov/pubmed/33746066
http://dx.doi.org/10.1016/j.biochi.2021.03.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130709/
https://www.ncbi.nlm.nih.gov/pubmed/33746066
http://dx.doi.org/10.1016/j.biochi.2021.03.009

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