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Intratumoural administration and tumour tissue targeting of cancer immunotherapies

Immune-checkpoint inhibitors and chimeric antigen receptor (CAR) T cells are revolutionizing oncology and haematology practice. With these and other immunotherapies, however, systemic biodistribution raises safety issues, potentially requiring the use of suboptimal doses or even precluding their cli...

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Detalles Bibliográficos
Autores principales: Melero, Ignacio, Castanon, Eduardo, Alvarez, Maite, Champiat, Stephane, Marabelle, Aurelien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130796/
https://www.ncbi.nlm.nih.gov/pubmed/34006998
http://dx.doi.org/10.1038/s41571-021-00507-y