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Predictive modeling of biological responses in the rat liver using in vitro Tox21 bioactivity: Benefits from high-throughput toxicokinetics
Computational methods are needed to more efficiently leverage data from in vitro cell-based models to predict what occurs within whole body systems after chemical insults. This study set out to test the hypothesis that in vitro high-throughput screening (HTS) data can more effectively predict in viv...
Autores principales: | Ring, Caroline, Sipes, Nisha S., Hsieh, Jui-Hua, Carberry, Celeste, Koval, Lauren E., Klaren, William D., Harris, Mark A., Auerbach, Scott S., Rager, Julia E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130852/ https://www.ncbi.nlm.nih.gov/pubmed/34013136 http://dx.doi.org/10.1016/j.comtox.2021.100166 |
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