Evaluating the fitness of PA/I38T-substituted influenza A viruses with reduced baloxavir susceptibility in a competitive mixtures ferret model

Baloxavir is approved in several countries for the treatment of uncomplicated influenza in otherwise-healthy and high-risk patients. Treatment-emergent viruses with reduced susceptibility to baloxavir have been detected in clinical trials, but the likelihood of widespread occurrence depends on repli...

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Detalles Bibliográficos
Autores principales: Lee, Leo Y, Zhou, Jie, Koszalka, Paulina, Frise, Rebecca, Farrukee, Rubaiyea, Baba, Keiko, Miah, Shahjahan, Shishido, Takao, Galiano, Monica, Hashimoto, Takashi, Omoto, Shinya, Uehara, Takeki, Mifsud, Edin J., Collinson, Neil, Kuhlbusch, Klaus, Clinch, Barry, Wildum, Steffen, Barclay, Wendy S., Hurt, Aeron C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130947/
https://www.ncbi.nlm.nih.gov/pubmed/33956888
http://dx.doi.org/10.1371/journal.ppat.1009527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130947/
https://www.ncbi.nlm.nih.gov/pubmed/33956888
http://dx.doi.org/10.1371/journal.ppat.1009527

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