Cargando…

Evaluating the fitness of PA/I38T-substituted influenza A viruses with reduced baloxavir susceptibility in a competitive mixtures ferret model

Baloxavir is approved in several countries for the treatment of uncomplicated influenza in otherwise-healthy and high-risk patients. Treatment-emergent viruses with reduced susceptibility to baloxavir have been detected in clinical trials, but the likelihood of widespread occurrence depends on repli...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Leo Y, Zhou, Jie, Koszalka, Paulina, Frise, Rebecca, Farrukee, Rubaiyea, Baba, Keiko, Miah, Shahjahan, Shishido, Takao, Galiano, Monica, Hashimoto, Takashi, Omoto, Shinya, Uehara, Takeki, Mifsud, Edin J., Collinson, Neil, Kuhlbusch, Klaus, Clinch, Barry, Wildum, Steffen, Barclay, Wendy S., Hurt, Aeron C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130947/ https://www.ncbi.nlm.nih.gov/pubmed/33956888 http://dx.doi.org/10.1371/journal.ppat.1009527

Ejemplares similares

Baloxavir treatment of ferrets infected with influenza A(H1N1)pdm09 virus reduces onward transmission
por: Lee, Leo Yi Yang, et al.
Publicado: (2020)

A rapid pyrosequencing assay for the molecular detection of influenza viruses with reduced baloxavir susceptibility due to PA/I38X amino acid substitutions
por: Koszalka, Paulina, et al.
Publicado: (2020)

Assessing the fitness of a dual-antiviral drug resistant human influenza virus in the ferret model
por: Stannard, Harry L., et al.
Publicado: (2022)

Infection with different human influenza A subtypes affects the period of susceptibility to secondary bacterial infections in ferrets
por: Mifsud, Edin J, et al.
Publicado: (2022)

Effect of Baloxavir and Oseltamivir in Combination on Infection with Influenza Viruses with PA/I38T or PA/E23K Substitutions in the Ferret Model
por: Koszalka, Paulina, et al.
Publicado: (2022)

Investigating the transmission of baloxavir‐resistant influenza viruses from treated index patients to untreated household contacts in the BLOCKSTONE study
por: Harding, Joanne, et al.
Publicado: (2023)

Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil
por: Omoto, Shinya, et al.
Publicado: (2018)

Characterising viable virus from air exhaled by H1N1 influenza-infected ferrets reveals the importance of haemagglutinin stability for airborne infectivity
por: Singanayagam, Anika, et al.
Publicado: (2020)

Baloxavir Marboxil in Japanese Pediatric Patients With Influenza: Safety and Clinical and Virologic Outcomes
por: Hirotsu, Nobuo, et al.
Publicado: (2020)

Carryover effects of baloxavir acid in human nasopharyngeal/pharyngeal swabs on infectious titer testing of influenza virus
por: Baba, Keiko, et al.
Publicado: (2020)

Predicting Permissive Mutations That Improve the Fitness of A(H1N1)pdm09 Viruses Bearing the H275Y Neuraminidase Substitution
por: Farrukee, Rubaiyea, et al.
Publicado: (2022)

The antiviral effects of baloxavir marboxil against influenza A virus infection in ferrets
por: Kitano, Mitsutaka, et al.
Publicado: (2020)

Comprehensive assessment of amino acid substitutions in the trimeric RNA polymerase complex of influenza A virus detected in clinical trials of baloxavir marboxil
por: Hashimoto, Takashi, et al.
Publicado: (2020)

LB16. Phase 3 Trial of Baloxavir Marboxil in High-Risk Influenza Patients (CAPSTONE-2 Study)
por: Ison, Michael G, et al.
Publicado: (2018)

Baloxavir Treatment in Adolescents With Acute Influenza: Subgroup Analysis From the CAPSTONE-1 Trial
por: Portsmouth, Simon, et al.
Publicado: (2020)

Retinoic Acid–Inducible Gene I Activation Inhibits Human Respiratory Syncytial Virus Replication in Mammalian Cells and in Mouse and Ferret Models of Infection
por: Schwab, Lara S U, et al.
Publicado: (2022)

1350. Therapeutic Effects of Baloxavir Marboxil against Influenza A Virus Infection in Ferrets
por: Kitano, Mitsutaka, et al.
Publicado: (2018)

Baloxavir Marboxil 2% Granules in Japanese Children With Influenza: An Open-label Phase 3 Study
por: Yokoyama, Takato, et al.
Publicado: (2020)

Baloxavir Marboxil Single-dose Treatment in Influenza-infected Children: A Randomized, Double-blind, Active Controlled Phase 3 Safety and Efficacy Trial (miniSTONE-2)
por: Baker, Jeffrey, et al.
Publicado: (2020)

Contact transmission of influenza virus between ferrets imposes a looser bottleneck than respiratory droplet transmission allowing propagation of antiviral resistance
por: Frise, Rebecca, et al.
Publicado: (2016)

Using the Ferret as an Animal Model for Investigating Influenza Antiviral Effectiveness
por: Oh, Ding Y., et al.
Publicado: (2016)

1645. Exploring Clinical and Antiviral Efficacy of Baloxavir Marboxil in a Phase 3, Randomized, Double-Blind, Placebo- and Active-Controlled Study of Otherwise Healthy Adults/Adolescents in Seasonal Influenza: Impact on Regional Participants, Treatment Time and Influenza Type B Virus Infection (CAPSTONE-1 Study)
por: Kawaguchi, Keiko, et al.
Publicado: (2018)

Influenza antivirals currently in late‐phase clinical trial
por: Koszalka, Paulina, et al.
Publicado: (2017)

A Novel Video Tracking Method to Evaluate the Effect of Influenza Infection and Antiviral Treatment on Ferret Activity
por: Oh, Ding Yuan, et al.
Publicado: (2015)

In Vivo Antiviral Activity of Baloxavir against PA/I38T-Substituted Influenza A Viruses at Clinically Relevant Doses
por: Kuroda, Takayuki, et al.
Publicado: (2023)

Favipiravir-resistant influenza A virus shows potential for transmission
por: Goldhill, Daniel H., et al.
Publicado: (2021)

Sequencing B cell receptors from ferrets (Mustela putorius furo)
por: Wong, Julius, et al.
Publicado: (2020)

Baloxavir safety and clinical and virologic outcomes in influenza virus-infected pediatric patients by age group: age-based pooled analysis of two pediatric studies conducted in Japan
por: Hirotsu, Nobuo, et al.
Publicado: (2023)

Utilising animal models to evaluate oseltamivir efficacy against influenza A and B viruses with reduced in vitro susceptibility
por: Farrukee, Rubaiyea, et al.
Publicado: (2020)

TaqMan real time RT-PCR assays for detecting ferret innate and adaptive immune responses
por: Carolan, Louise A., et al.
Publicado: (2014)

Modeling mitigation of influenza epidemics by baloxavir
por: Du, Zhanwei, et al.
Publicado: (2020)

Prophylactic Treatment with Baloxavir Protects Mice from Lethal Infection with Influenza A and B Viruses
por: Fukao, Keita, et al.
Publicado: (2023)

Host Cell Restriction Factors of Paramyxoviruses and Pneumoviruses
por: Farrukee, Rubaiyea, et al.
Publicado: (2020)

Isoforms of Human MARCH1 Differ in Ability to Restrict Influenza A Viruses Due to Differences in Their N Terminal Cytoplasmic Domain
por: Villalón-Letelier, Fernando, et al.
Publicado: (2022)

Determining the Mutation Bias of Favipiravir in Influenza Virus Using Next-Generation Sequencing
por: Goldhill, Daniel H., et al.
Publicado: (2019)

Viral burden, inflammatory milieu and CD8(+) T‐cell responses to influenza virus in a second‐generation thiazolide (RM‐5061) and oseltamivir combination therapy study
por: Nüssing, Simone, et al.
Publicado: (2020)

1343. Prophylactic Dosing of Baloxavir Acid Eliminates Mortality in Mice Lethal Influenza A Virus Infection Model
por: Shano, Shinya, et al.
Publicado: (2018)

Efficacy of baloxavir marboxil on household transmission of influenza infection
por: Umemura, Takumi, et al.
Publicado: (2020)

Baloxavir Marboxil: An Original New Drug against Influenza
por: Dufrasne, François
Publicado: (2021)

Polymer formulated self-amplifying RNA vaccine is partially protective against influenza virus infection in ferrets
por: McKay, P F, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_9s63vmpvee265eehcb60jo3nij