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Constitutive activation of MEK5 promotes a mesenchymal and migratory cell phenotype in triple negative breast cancer

Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited targeted therapeutic options. A defining feature of TNBC is the propensity to metastasize and acquire resistance to cytotoxic agents. Mitogen activated protein kinase (MAPK) and extracellular regulated kinase...

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Detalles Bibliográficos
Autores principales: Matossian, Margarite D., Hoang, Van T., Burks, Hope E., La, Jacqueline, Elliott, Steven, Brock, Courtney, Rusch, Douglas B., Buechlein, Aaron, Nephew, Kenneth P., Bhatt, Akshita, Cavanaugh, Jane E., Flaherty, Patrick T., Collins-Burow, Bridgette M., Burow, Matthew E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131078/
https://www.ncbi.nlm.nih.gov/pubmed/34026925
http://dx.doi.org/10.18632/oncoscience.535