Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation

Virus propagation methods generally use transformed cell lines to grow viruses from clinical specimens, which may force viruses to rapidly adapt to cell culture conditions, a process facilitated by high viral mutation rates. Upon propagation in VeroE6 cells, SARS-CoV-2 may mutate or delete the multi...

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Detalles Bibliográficos
Autores principales: Lamers, Mart M, Mykytyn, Anna Z, Breugem, Tim I, Wang, Yiquan, Wu, Douglas C, Riesebosch, Samra, van den Doel, Petra B, Schipper, Debby, Bestebroer, Theo, Wu, Nicholas C, Haagmans, Bart L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131099/
https://www.ncbi.nlm.nih.gov/pubmed/33835028
http://dx.doi.org/10.7554/eLife.66815

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131099/
https://www.ncbi.nlm.nih.gov/pubmed/33835028
http://dx.doi.org/10.7554/eLife.66815

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