Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist

Interleukin-2 is a pleiotropic cytokine that mediates both pro- and anti-inflammatory functions. Immune cells naturally differ in their sensitivity to IL-2 due to cell type and activation state-dependent expression of receptors and signaling pathway components. To probe differences in IL-2 signaling...

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Detalles Bibliográficos
Autores principales: Glassman, Caleb R, Su, Leon, Majri-Morrison, Sonia S, Winkelmann, Hauke, Mo, Fei, Li, Peng, Pérez-Cruz, Magdiel, Ho, Peggy P, Koliesnik, Ievgen, Nagy, Nadine, Hnizdilova, Tereza, Picton, Lora K, Kovar, Marek, Bollyky, Paul, Steinman, Lawrence, Meyer, Everett, Piehler, Jacob, Leonard, Warren J, Garcia, K Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131104/
https://www.ncbi.nlm.nih.gov/pubmed/34003116
http://dx.doi.org/10.7554/eLife.65777

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131104/
https://www.ncbi.nlm.nih.gov/pubmed/34003116
http://dx.doi.org/10.7554/eLife.65777

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