Direct Comparison of the Prediction of the Unbound Brain-to-Plasma Partitioning Utilizing Machine Learning Approach and Mechanistic Neuropharmacokinetic Model

The mechanistic neuropharmacokinetic (neuroPK) model was established to predict unbound brain-to-plasma partitioning (K(p,uu,brain)) by considering in vitro efflux activities of multiple drug resistance 1 (MDR1) and breast cancer resistance protein (BCRP). Herein, we directly compare this model to a...

Descripción completa

Detalles Bibliográficos
Autores principales: Kosugi, Yohei, Mizuno, Kunihiko, Santos, Cipriano, Sato, Sho, Hosea, Natalie, Zientek, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131289/
https://www.ncbi.nlm.nih.gov/pubmed/34008121
http://dx.doi.org/10.1208/s12248-021-00604-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131289/
https://www.ncbi.nlm.nih.gov/pubmed/34008121
http://dx.doi.org/10.1208/s12248-021-00604-x

Ejemplares similares