The effect of mitochondrial calcium uniporter and cyclophilin D knockout on resistance of brain mitochondria to Ca(2+)-induced damage

The mitochondrial calcium uniporter (MCU) and cyclophilin D (CyD) are key players in induction of the permeability transition pore (PTP), which leads to mitochondrial depolarization and swelling, the major signs of Ca(2+)-induced mitochondrial damage. Mitochondrial depolarization inhibits ATP produc...

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Detalles Bibliográficos
Autores principales: Hamilton, James, Brustovetsky, Tatiana, Brustovetsky, Nickolay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131324/
https://www.ncbi.nlm.nih.gov/pubmed/33864812
http://dx.doi.org/10.1016/j.jbc.2021.100669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131324/
https://www.ncbi.nlm.nih.gov/pubmed/33864812
http://dx.doi.org/10.1016/j.jbc.2021.100669

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