Cargando…

G protein-coupled receptor kinase 5 deletion suppresses synovial inflammation in a murine model of collagen antibody-induced arthritis

G protein-coupled receptor kinase 5 (GRK5) regulates inflammatory responses via the nuclear factor-kappa B (NF-κB) pathway. This study investigated the functional involvement of GRK5 in the pathogenesis of inflammatory arthritis. Immunohistochemically, rheumatoid arthritis (RA) synovium had a signif...

Descripción completa

Detalles Bibliográficos
Autores principales:	Toya, Masakazu, Akasaki, Yukio, Sueishi, Takuya, Kurakazu, Ichiro, Kuwahara, Masanari, Uchida, Taisuke, Tsutsui, Tomoaki, Tsushima, Hidetoshi, Yamada, Hisakata, Lotz, Martin K., Nakashima, Yasuharu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131379/ https://www.ncbi.nlm.nih.gov/pubmed/34006987 http://dx.doi.org/10.1038/s41598-021-90020-0

Ejemplares similares

Fluvastatin promotes chondrogenic differentiation of adipose-derived mesenchymal stem cells by inducing bone morphogenetic protein 2
por: Kuwahara, Masanari, et al.
Publicado: (2022)

Preoperative Virtual Total Knee Arthroplasty Surgery Using a Computed Tomography-based 3-dimensional Model With Variation in Reference Points and Target Alignment to Predict Femoral Component Sizing
por: Ishibashi, Shojiro, et al.
Publicado: (2022)

Improved surgical procedure of primary constrained total knee arthroplasty which enables use of the femoral diaphyseal straight extension stem
por: Kawahara, Shinya, et al.
Publicado: (2022)

Sagittal femoral bowing contributes to distal femoral valgus angle deviation in malrotated preoperative radiographs
por: Kokubu, Yasuhiko, et al.
Publicado: (2022)

Factors affecting patient satisfaction related to cost and treatment effectiveness in rheumatoid arthritis: results from the multicenter observational cohort study, FRANK Registry
por: Fujiwara, Toshifumi, et al.
Publicado: (2022)

Th1 is the predominant helper T cell subset that produces GM-CSF in the joint of rheumatoid arthritis
por: Yamada, Hisakata, et al.
Publicado: (2017)

Prognostic factors for the short-term mortality of patients with rheumatoid arthritis admitted to intensive care units
por: Fujiwara, Toshifumi, et al.
Publicado: (2020)

Interaction between functional capability and sleep quality at midterm after total knee arthroplasty: a Japanese retrospective cohort study
por: Hamai, Satoshi, et al.
Publicado: (2023)

Anterior cruciate ligament reconstruction in a patient who has received systemic steroids for autoimmune disease
por: Ushio, Tetsuro, et al.
Publicado: (2017)

Arthroscopic Treatment of Septic Arthritis of the Ankle Caused by Group B Streptococcus: A Case Report
por: Soejima, Yu, et al.
Publicado: (2023)

Isolation and Characterization of Synovial Mesenchymal Stem Cells Derived From Patients With Chronic Lateral Ankle Instability: A Comparative Analysis of Synovial Fluid, Adipose Synovium, and Fibrous Synovium of the Ankle Joint
por: Nakashima, Hirotaka, et al.
Publicado: (2022)

Influence of dioxin-related compounds on physical function in Yusho incident victims
por: Fukushi, Jun-ichi, et al.
Publicado: (2019)

IMMU-12. PHASE I/II TRIAL OF IMMUNOTHERAPY WITH FUSIONS OF DENDRITIC CELLS AND TUMOR CELLS FOR RELAPSED OR REFRACTORY BRAIN TUMORS IN CHILDREN AND YOUNG ADULTS
por: Yamaoka, Masayoshi, et al.
Publicado: (2020)

The Effect of Synovial Fluid Enzymes on the Biodegradability of Collagen and Fibrin Clots
por: Palmer, Matthew, et al.
Publicado: (2011)

Deep learning-based automatic-bone-destruction-evaluation system using contextual information from other joints
por: Miyama, Kazuki, et al.
Publicado: (2022)

Integrin β1, PDGFRβ, and type II collagen are essential for meniscus regeneration by synovial mesenchymal stem cells in rats
por: Kitahashi, Tsukasa, et al.
Publicado: (2022)

Suppression of murine collagen-induced arthritis by targeted apoptosis of synovial neovasculature
por: Gerlag, Danielle M, et al.
Publicado: (2001)

Effects of betulinic acid on synovial inflammation in rats with collagen-induced arthritis
por: Kun-Liu,, et al.
Publicado: (2020)

Transthyretin deposition promotes progression of osteoarthritis
por: Matsuzaki, Tokio, et al.
Publicado: (2017)

Effects of G-gene Deletion and Replacement on Rabies Virus Vector Gene Expression
por: Sato, Sho, et al.
Publicado: (2015)

Isolation and Characterization of Synovial Mesenchymal Stem Cell Derived from Hip Joints: A Comparative Analysis with a Matched Control Knee Group
por: Hatakeyama, Akihisa, et al.
Publicado: (2017)

Case report: A case of severe retropharyngeal edema after COVID-19 successfully treated with intravenous immunoglobulin
por: Suzuki, Takanori, et al.
Publicado: (2023)

A novel type II collagen gene mutation in a family with spondyloepiphyseal dysplasia and extensive intrafamilial phenotypic diversity
por: Nakashima, Yasuharu, et al.
Publicado: (2016)

Gene expression profile and synovial microcirculation at early stages of collagen-induced arthritis
por: Gierer, Philip, et al.
Publicado: (2005)

Lysyl oxidase is involved in synovial hyperplasia and angiogenesis in rats with collagen-induced arthritis
por: Wang, Fan, et al.
Publicado: (2017)

Interleukin-21 signaling in B cells, but not in T cells, is indispensable for the development of collagen-induced arthritis in mice
por: Sakuraba, Koji, et al.
Publicado: (2016)

Drug delivery options to increase patient adherence and satisfaction in the management of rheumatoid arthritis – focus on subcutaneous tocilizumab
por: Nakashima, Yasuharu, et al.
Publicado: (2014)

Relaxin's induction of metalloproteinases is associated with the loss of collagen and glycosaminoglycans in synovial joint fibrocartilaginous explants
por: Naqvi, Tabassum, et al.
Publicado: (2005)

Collagen V oral administration decreases inflammation and remodeling of synovial membrane in experimental arthritis
por: Atayde, Silvana Ramos, et al.
Publicado: (2018)

Rabies Virus Vector Transgene Expression Level and Cytotoxicity Improvement Induced by Deletion of Glycoprotein Gene
por: Ohara, Shinya, et al.
Publicado: (2013)

Characteristics of MSCs in Synovial Fluid and Mode of Action of Intra-Articular Injections of Synovial MSCs in Knee Osteoarthritis
por: Sekiya, Ichiro, et al.
Publicado: (2021)

Targeted conditional collagen XII deletion alters tendon function
por: Fung, Ashley, et al.
Publicado: (2022)

Dynamics of early synovial cytokine expression in rodent collagen-induced arthritis: a therapeutic study
por: Palmblad, K, et al.
Publicado: (2001)

CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis
por: Karpus, Olga N, et al.
Publicado: (2015)

Alleviation of Synovial Inflammation of Juanbi-Tang on Collagen-Induced Arthritis and TNF-Tg Mice Model
por: Wang, Tengteng, et al.
Publicado: (2020)

Etodolac improves collagen induced rheumatoid arthritis in rats by inhibiting synovial inflammation, fibrosis and hyperplasia
por: Feng, Qin, et al.
Publicado: (2021)

Characteristics of lumbar scoliosis in patients with rheumatoid arthritis
por: Ohishi, Masanobu, et al.
Publicado: (2014)

A partial supernumerary umbilical vein: a case report
por: Kurakazu, Mariko, et al.
Publicado: (2019)

Current perspectives on the role of IL-17 in autoimmune disease
por: Yamada, Hisakata
Publicado: (2010)

The Search for the Pathogenic T Cells in the Joint of Rheumatoid Arthritis: Which T-Cell Subset Drives Autoimmune Inflammation?
por: Yamada, Hisakata
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_efgepkonon02pq4ipbrqoslvgm