Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation

Depleting the microenvironment of important nutrients such as arginine is a key strategy for immune evasion by cancer cells. Many tumors overexpress arginase, but it is unclear how these cancers, but not T cells, tolerate arginine depletion. In this study, we show that tumor cells synthesize arginin...

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Detalles Bibliográficos
Autores principales: Crump, Nicholas T., Hadjinicolaou, Andreas V., Xia, Meng, Walsby-Tickle, John, Gileadi, Uzi, Chen, Ji-Li, Setshedi, Mashiko, Olsen, Lars R., Lau, I-Jun, Godfrey, Laura, Quek, Lynn, Yu, Zhanru, Ballabio, Erica, Barnkob, Mike B., Napolitani, Giorgio, Salio, Mariolina, Koohy, Hashem, Kessler, Benedikt M., Taylor, Stephen, Vyas, Paresh, McCullagh, James S.O., Milne, Thomas A., Cerundolo, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131582/
https://www.ncbi.nlm.nih.gov/pubmed/33979616
http://dx.doi.org/10.1016/j.celrep.2021.109101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131582/
https://www.ncbi.nlm.nih.gov/pubmed/33979616
http://dx.doi.org/10.1016/j.celrep.2021.109101

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